Smile, dream big and spread positive vibes ... that is how Saudi siblings Hamzah and Hanaa Iskandar fought their battles with cancer, becoming two of the kingdom's most inspirational cancer warriors.

Unfortunately, Saudi Arabia has lost both Iskandar siblings to cancer this year.

This January, the world mourned the loss of Hamzahblogger, influencer and motivational speaker who inspired people to "fight cancer with a smile".

Despite her heartbreak and personal struggle with the disease, his sister Hanaa carried on his legacy and continued to spread positive vibes.

“My brother fought cancer with a smile and I will do the same,” Hanaa said at the time. 

Today, we woke up to the news of 24-year-old Hanaa's passing, after suffering from Stage 4 sarcoma - a cancerous tumor of connective or other nonepithelial tissue - for almost one year.

Known for having a heartwarming relationship and spreading optimism on social media, the Iskandar siblings have left a mark in the hearts of many.

After news of Hanaa's passing broke, people took to social media to express their condolences and share heartfelt messages:

The world lost a beacon of hope

She kept a smile on her face throughout the hardships

"We will all smile for you"

The kingdom has lost two of its most inspirational cancer warriors

"We belong to Allah and to Him we shall return. Hanaa Iskandar moved to the mercy of Allah, following her brother Hamzah ... the most famous cancer warriors."

Many are praying for her parents to stay strong

"God forgive her and grant her parents patience." 

Beautiful souls that left a mark on the hearts of many

"When beautiful souls die, they deserve prayer. God forgive them. They left a beautiful print in the hearts of many." 

"Hanaa Iskandar passed away, and Hamzah passed before her. But their smiles did not leave. They will remain ingrained in our hearts. God grant them heaven and help their parents."

RIP Hanaa and Hamzah ... You will be missed