Karam, who has appeared on several late night shows, TV series and films, is expected to star in a stand-up comedy special which will be shot in Beirut's renowned Casino Du Liban.
The name of the show has yet to be revealed.
"I am very happy and excited to be a part of Netflix’s first original production to be produced in the Middle East. It is a great honor and privilege and I can’t wait to embark on this new adventure," Karam said in a statement.
According to Hollywood Reporter, the show is expected to launch in 2018 in all Netflix territories around the world.
The comedy special, produced by Creative Arab Talent, aims to touch on a variety of subjects including relationships and social issues.
Vice president of the International Original Series at Netflix, Erik Barmack, said, "Adel Karam is a very strong voice in comedy. We are extremely excited to collaborate with him, and can’t wait for the local audience, who have a deep appreciation of comedy, to watch the show as well as to introduce him to our global audience."