An explosion blasted through Manchester Arena - Britain's largest indoor venue - on Monday evening, killing at least 22 people and injuring 59 others.

The attack appears to have been a suicide bombing and went off right outside the main hall of the venue as Ariana Grande's concert came to an end.

The American pop singer tweeted out a message to all those affected by the tragic attack: 

"Broken. From the bottom of my heart, I am so so sorry. I don't have words," Grande wrote. 

The greater Manchester police say the perpetrator was a man acting alone. The bomber died at the scene after detonating the explosive device.

Soon after the horrific news, Home Secretary Amber Rudd spoke out calling it "a barbaric attack, deliberately targeting some of the most vulnerable in our society".

Some have lost their loved ones in the midst of all the chaos, using the hashtag #MissingInManchester in an effort to find all those who have disappeared.  

"You could feel it in your chest," said attendee Catherine Macfarlane, according to NBC News

"It was chaotic. Everybody was running and screaming and just trying to get out," she added. 

Arabs from all over the world came together in light of the tragedy, sending heartfelt messages to all those affected. 

Realizing that teens were among the victims missing, dead and injured

It's really "a whole different level of evil"

"Numb"

#PrayForManchester

Faith in humanity shot down ... but acts of humanity spread a ray of hope

"Pure evil"

"Horrendous"

Truly heartbreaking